Glioblastoma

Synonyms

Astrocytoma, Grade IV

Astrocytomas, Grade IV

Giant Cell Glioblastoma

Giant Cell Glioblastomas

Glioblastoma Multiforme

Glioblastoma, Giant Cell

Glioblastomas

Glioblastomas, Giant Cell

Grade IV Astrocytoma

Grade IV Astrocytomas

A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.