Histamine H1 Antagonists
Synonyms
Antagonists, Histamine H1
Antagonists, Histamine H1 Receptor
Antihistamines, Classical
Antihistamines, Sedating
Antihistaminics, Classical
Antihistaminics, H1
Blockaders, Histamine H1 Receptor
Classical Antihistamines
Classical Antihistaminics
First Generation H1 Antagonists
H1 Antagonists, Histamine
H1 Antihistaminics
H1 Receptor Blockaders
Histamine H1 Blockers
Histamine H1 Receptor Antagonists
Histamine H1 Receptor Blockaders
Receptor Blockaders, H1
Sedating Antihistamines
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.