Homogentisate 1,2-Dioxygenase

Synonyms

1,2-Dioxygenase, Homogentisate

Acid Oxidase, Homogentisic

Dioxygenase, Homogentisate

Homogentisate 1,2 Dioxygenase

Homogentisate Dioxygenase

Homogentisate Oxidase

Homogentisate Oxygenase

Homogentisic Acid Oxidase

Oxidase, Homogentisate

Oxidase, Homogentisic Acid

Oxygenase, Homogentisate

A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.

See Also