Immunoglobulin Class Switching

Synonyms

Class Switching

Class Switching, Immunoglobulin

Class Switchings

Class Switchings, Immunoglobulin

Immunoglobulin Class Switchings

Isotype Switching

Isotype Switchings

Switching, Class

Switching, Immunoglobulin Class

Switching, Isotype

Switchings, Class

Switchings, Immunoglobulin Class

Switchings, Isotype

Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.