L Type Voltage Dependent Calcium Channels

Long-lasting voltage-gated Calcium Channels found in both excitable and nonexcitable Tissue. They are responsible for normal myocardial and Vascular Smooth Muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the Binding Site for Calcium-based antagonists. Dihydropyridine-based Calcium antagonists are used as markers for these Binding Sites.