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MAP Kinase Kinase Kinases

Mitogen-activated Protein Kinase Kinase Kinases (MAPKKKs) are Serine-Threonine Protein Kinases that initiate Protein Kinase signaling cascades. They phosphorylate Mitogen-Activated Protein Kinase Kinases; (MAPKKs) which in turn phosphorylate Mitogen-Activated Protein Kinases; (MAPKs).