Myelinolysis, Central Pontine

Synonyms

Central Pontine Myelinoclasis

Central Pontine Myelinolysis

Extrapontine Myelinoclases

Extrapontine Myelinoclasis

Extrapontine Myelinolyses

Extrapontine Myelinolysis

Myelinoclases, Extrapontine

Myelinoclasis, Central Pontine

Myelinoclasis, Extrapontine

Myelinolyses, Extrapontine

Myelinolysis, Extrapontine

Pontine Myelinolysis, Central

A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)