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N Acetyl beta D hexosaminidase

A Hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; Galactosides; and several Oligosaccharides. Two specific mammalian Isoenzymes of beta-N-acetylhexoaminidase are referred to as Hexosaminidase A and Hexosaminidase B. Deficiency of the type A isoenzyme causes Tay-Sachs Disease, while deficiency of both A and B Isozymes causes Sandhoff Disease. The enzyme has also been used as a Tumor marker to distinguish between malignant and benign Disease.