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O Acetyl ADP Ribose

An acetyl ester of Adenosine Diphosphate Ribose formed during NAD-dependent deacetylation of Proteins by Sirtuins. The acetate group resides on the Ribose ring where Nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-Ribose have been isolated from the reaction.