Paraneoplastic Cerebellar Degeneration

Synonyms

Anti Yo Associated Paraneoplastic Cerebellar Degeneration

Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration

Cerebellar Degeneration, Paraneoplastic

Cerebellar Syndrome, Paraneoplastic

Cerebellar Syndromes, Paraneoplastic

Degeneration, Paraneoplastic Cerebellar

Paraneoplastic Cerebellar Degeneration, Anti Yo Associated

Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated

Paraneoplastic Cerebellar Syndrome

Paraneoplastic Cerebellar Syndromes

Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)