Protoporphyrinogen Oxidase
Synonyms
Dehydrogenase, Protoporphyrinogen
Oxidase, Protoporphyrinogen
Oxidase, Protoporphyrinogen IX
Protoporphyrinogen Dehydrogenase
Protoporphyrinogen IX Oxidase
Protoporphyrinogenase
Protox
A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase.