Retinoblastoma-Like Protein p130
Synonyms
RBL2 Protein
Retinoblastoma Like Protein 2
Retinoblastoma Like Protein p130
Retinoblastoma-Like Protein 2
p130, Retinoblastoma-Like Protein
A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.