Selective Estrogen Receptor Modulators
Synonyms
Estrogen Receptor Modulator, Selective
Estrogen Receptor Modulators, Selective
SERM
SERMs
Selective Estrogen Receptor Modulator
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
See Also