Sirolimus

Synonyms

AY 22 989

AY 22-989

AY 22989

I 2190A

I-2190A

I2190A

Rapamune

Rapamycin

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.