Steroid 12-alpha-Hydroxylase

Synonyms

12 alpha Hydroxylase

12 alpha-Hydroxylase, Sterol

12-alpha-Hydroxylase

12alpha Hydroxylase

12alpha-Hydroxylase

CYP8B1

Cytochrome P450 8B1

Cytochrome P450 CYP8B1

Steroid 12 Hydroxylase

Steroid 12 Monooxygenase

Steroid 12 alpha Hydroxylase

Steroid 12-Hydroxylase

Steroid 12-Monooxygenase

Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)

Steroid-12-Hydroxylase

Steroid-12-Monooxygenase

Sterol 12 alpha Hydroxylase

Sterol 12 alpha-Hydroxylase

Sterol 12-alpha-Hydroxylase

alpha-Hydroxylase, Sterol 12

A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.