Supranuclear Palsy, Progressive
Synonyms
Ophthalmoplegia, Progressive Supranuclear
Palsy, Progressive Supranuclear
Progressive Supranuclear Ophthalmoplegia
Progressive Supranuclear Palsies
Progressive Supranuclear Palsy
Richardson Syndrome
Richardson's Syndrome
Steele Richardson Olszewski Disease
Steele Richardson Olszewski Syndrome
Steele-Richardson-Olszewski Disease
Steele-Richardson-Olszewski Syndrome
Supranuclear Ophthalmoplegia, Progressive
Supranuclear Palsies, Progressive
Supranuclear Palsy, Progressive, 1
Syndrome, Richardson's
Syndrome, Steele-Richardson-Olszewski
A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)