T Lymphocytes, Cytotoxic

Immunized T-Lymphocytes which can directly destroy appropriate target Cells. These cytotoxic Lymphocytes may be generated In Vitro in mixed Lymphocyte Cultures (MLC), in vivo during a Graft-versus-host (GVH) reaction, or after Immunization with an Allograft, Tumor Cell or virally transformed or chemically modified target Cell. The lytic phenomenon is sometimes referred to as Cell-mediated lympholysis (CML). These CD8-positive Cells are distinct from Natural Killer Cells and Natural Killer T-Cells. There are two effector Phenotypes: TC1 and TC2.