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Tumor Necrosis Factor

Serum Glycoprotein produced by activated Macrophages and other mammalian Mononuclear Leukocytes. It has necrotizing activity against Tumor Cell Lines and increases ability to reject Tumor Transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (Lymphotoxin), but they share TNF Receptors.