v erbA Proteins

Transforming Proteins encoded by erbA Oncogenes from the Avian Erythroblastosis Virus. They are truncated versions of c-erbA, the Thyroid Hormone Receptor (Receptors, Thyroid Hormone) that have retained both the DNA-binding and Hormone-binding domains. Mutations in the Hormone-binding domains abolish the Transcriptional Activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.