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V erbA Related Protein EAR 1

A DNA-binding Orphan nuclear receptor that negatively regulates expression of ARNTL Transcription Factors and plays a Role as a regulatory component of the Circadian Clock System. The Nr1d1 nuclear receptor expression is cyclically-regulated by a Feedback loop involving its positive Regulation by CLOCK Protein; BMAL1 PROTEIN heterodimers and its negative Regulation by Cryptochrome and Period Proteins.