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v fms Protein

Transforming Glycoprotein coded by the fms Oncogene from the Susan McDonough strain of feline Sarcoma Virus (SM-FeSV). The Oncogene Protein v-fms lacks sequences, which, in the highly homologous proto-Oncogene Protein c-fms (CSF-1 Receptor), normally serve to regulate its Tyrosine Kinase activity. The missing sequences in v-fms mimic the effect of ligand and Lead to constitutive Cell Growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).