Wagenmann Froboese Syndrome

Similar to MEN2a, it is also caused by Mutations of the MEN2 Gene, also known as the RET Proto-Oncogene. Its clinical symptoms include Medullary Carcinoma (Carcinoma, Medullary) of Thyroid Gland and Pheochromocytoma of Adrenal Medulla (50%). Unlike MEN2a, MEN2b does not involve Parathyroid Neoplasms. It can be distinguished from MEN2a by its neural abnormalities such as mucosal Neuromas on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of Gastrointestinal Tract leading to Megacolon. It is an autosomal dominant inherited Disease.