A Disintegrin And Metalloproteinase With Thrombospondin Motifs Proteins
ADAMTS Like Proteins
Adam Metallopeptidases With Thrombospondin Type 1 Motif Proteins
A subfamily of ADAM proteases that are distinguished by the presence of one or more THROMBOSPONDIN type-1 repeats (TSRs). These are three-strand motifs that contain characteristic TRYPTOPHAN, ARGININE, and CYSTEINE residues respectively. In contrast to ADAM proteins, which reside on CELL MEMBRANES, ADAMTS proteases are secreted and function in the EXTRACELLULAR MATRIX.