Antigens, CD40


Antigen, CD40

Antigen, CDw40

CD40 Antigen

CD40 Antigens

CDw40 Antigen

Receptor, TNFRSF5

TNFRSF5 Receptor

Tumor Necrosis Factor Receptor Superfamily, Member 5

A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

See Also