Colorectal Neoplasms, Hereditary Nonpolyposis
Synonyms
Colon Cancer, Familial Nonpolyposis
Colorectal Cancer Hereditary Nonpolyposis
Familial Nonpolyposis Colon Cancer
Hereditary Nonpolyposis Colon Cancer
Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Neoplasms
Lynch Cancer Family Syndrome I
Lynch Syndrome
Lynch Syndrome I
Syndrome, Lynch
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.