Costello Syndrome


FCS Syndrome

FCS Syndromes

Faciocutaneoskeletal Syndrome

Faciocutaneoskeletal Syndromes

Syndrome, Costello

Syndrome, FCS

Syndrome, Faciocutaneoskeletal

Syndromes, FCS

Syndromes, Faciocutaneoskeletal

Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome).