Cytochrome P-450 Enzyme System
Synonyms
CYP450 Family
CYP450 Superfamily
Cytochrome P 450
Cytochrome P 450 Dependent Monooxygenase
Cytochrome P 450 Enzyme System
Cytochrome P 450 Enzymes
Cytochrome P 450 Families
Cytochrome P 450 Monooxygenase
Cytochrome P 450 Oxygenase
Cytochrome P 450 Superfamily
Cytochrome P-450
Cytochrome P-450 Enzymes
Cytochrome P-450 Families
Cytochrome P-450 Monooxygenase
Cytochrome P-450 Oxygenase
Cytochrome P-450 Superfamily
Cytochrome P-450-Dependent Monooxygenase
Cytochrome P450
Cytochrome P450 Superfamily
Cytochrome p450 Families
Enzymes, Cytochrome P-450
Enzymes, P-450
Enzymes, P450
Monooxygenase, Cytochrome P-450
Monooxygenase, Cytochrome P-450-Dependent
P 450 Enzymes
P-450 Enzymes
P-450 Enzymes, Cytochrome
P450 Enzymes
Superfamily, CYP450
Superfamily, Cytochrome P-450
Superfamily, Cytochrome P450
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.