DEAD Box Protein 58
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
Probable ATP Dependent RNA Helicase DDX58
Probable ATP-Dependent RNA Helicase DDX58
RIG I like Receptor 1
RIG-I-like Receptor 1
A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).