Dishevelled Proteins


Dishevelled 1 Protein

Dishevelled 2 Protein

Dishevelled 3 Protein

Dishevelled Protein

Dishevelled-1 Protein

Dishevelled-2 Protein

Dishevelled-3 Protein

A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.