Enhancer of Zeste Homolog 2 Protein


EZH2, Histone-Lysine N-Methyltransferase

Enhancer of Zeste Homolog 2

Histone Lysine N Methyltransferase EZH2

Histone-Lysine N-Methyltransferase EZH2

Lysine N Methyltransferase 6

Lysine N-Methyltransferase-6

A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation at the PROMOTER REGIONS of the circadian genes and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.