Ferrochelatase
Synonyms
Chelatase, Porphyrin-Metal
Chelatase, Zinc
Ferro-Lyase, Protoheme
Heme Synthetase
Porphyrin Metal Chelatase
Porphyrin-Metal Chelatase
Protoheme Ferro Lyase
Protoheme Ferro-Lyase
Protoheme ferro-lyase
Synthetase, Heme
Zinc Chelatase
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.