Folic Acid Antagonists
Synonyms
Acid Antagonists, Folic
Antagonists, Folic Acid
Antifolates
Dihydrofolate Reductase Inhibitors
Folic Acid Metabolism Inhibitors
Inhibitors, Dihydrofolate Reductase
Reductase Inhibitors, Dihydrofolate
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)