Autocrine Motility Factor
Glucose 6 Phosphate Isomerase
Isomerase, Glucose 6 Phosphate
Motility Factor, Autocrine
Tumor Autocrine Motility Factor
Tumor Cell Autocrine Motility Factor
Tumor-Cell Autocrine Motility Factor
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.