Immunoglobulin Class Switching
Class Switching, Immunoglobulin
Class Switchings, Immunoglobulin
Immunoglobulin Class Switchings
Switching, Immunoglobulin Class
Switchings, Immunoglobulin Class
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.