Insulin Receptor Substrate Proteins
Synonyms
IRS Signaling Adaptor Proteins
Insulin Receptor Substrate 1
Insulin Receptor Substrate 1 Protein
Insulin Receptor Substrate 2
Insulin Receptor Substrate 2 Protein
Insulin Receptor Substrate 3
Insulin Receptor Substrate 3 Protein
Insulin Receptor Substrate 4
Insulin Receptor Substrate 4 Protein
Insulin Receptor Substrate-1
Insulin Receptor Substrate-1 Protein
Insulin Receptor Substrate-2
Insulin Receptor Substrate-2 Protein
Insulin Receptor Substrate-3
Insulin Receptor Substrate-3 Protein
Insulin Receptor Substrate-4
Insulin Receptor Substrate-4 Protein
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.