Lactase Phlorizin Hydrolase
The multifunctional protein that contains two enzyme domains. The first domain (EC 220.127.116.11) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 18.104.22.168) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.