Lafora Disease


Disease, Lafora

Disease, Lafora Body

Disorder, Lafora Body

Epilepsy Progressive Myoclonic 2

Epilepsy, Progressive Myoclonic 2A

Epilepsy, Progressive Myoclonic, Lafora

Lafora Body Disease

Lafora Body Disease, Late Onset

Lafora Body Disorder

Lafora Myoclonic Epilepsy

Lafora Progressive Myoclonic Epilepsy

Lafora Progressive Myoclonus Epilepsy

Lafora Type Progressive Myoclonic Epilepsy

Lafora-Body Disease, Late Onset

Late Onset Lafora Body Disease

Myoclonic Epilepsy of Lafora

Progressive Myoclonic Epilepsy Type 2

Progressive Myoclonic Epilepsy, Lafora

Progressive Myoclonic Epilepsy, Lafora Type

Progressive Myoclonus Epilepsy, Lafora Type

A form of stimulus sensitive myoclonic epilepsy inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110)