MAP Kinase Signaling System


Cascade, MAP Kinase

ERK Pathway

ERK Pathways

ERK Signal Tranduction Pathway

ERK1 2 Pathway

ERK1 and ERK2 Pathway

ERK1-2 Pathway

ERK1-2 Pathways

JNK Pathway

JNK Pathways

JNK Signaling Pathway

JNK Signaling Pathways

Kinase Cascade, MAP

Kinase Pathway, p38

Kinase Pathways, p38

MAP Kinase Cascade

MAP Kinase Cascades

MAP Kinase Module

MAP Kinase Modules

MAP Kinase Signaling Cascades

MAP Kinase Signaling Pathways

MEK ERK Pathway

MEK-ERK Pathway

MEK-ERK Pathways

Module, MAP Kinase

Pathway, ERK

Pathway, ERK1-2

Pathway, JNK

Pathway, JNK Signaling

Pathway, MEK-ERK

Pathway, p38 Kinase

Pathways, ERK

Pathways, ERK1-2

Pathways, JNK

Pathways, JNK Signaling

Pathways, MEK-ERK

Pathways, p38 Kinase

Signaling Pathway, JNK

Signaling Pathways, JNK

p38 Kinase Pathway

p38 Kinase Pathways

p38 Kinase Signaling Pathway

An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.