Metabolic Detoxication, Phase I

Synonyms

Detoxication, Oxidative Metabolic

Detoxications, Oxidative Metabolic

Detoxification, Phase I

Detoxifications, Phase I

Metabolic Detoxication, Oxidative

Metabolic Detoxications, Oxidative

Metabolic Detoxification, Phase I

Oxidative Metabolic Detoxication

Oxidative Metabolic Detoxications

Phase I Detoxification

Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.