Multiple Endocrine Neoplasia Type 2b

Synonyms

MEA 2b

MEA IIb

MEN 2b

MEN 3

MEN III

MEN IIb

MEN2b

Mucosal Neuroma Syndrome

Mucosal Neuroma Syndromes

Multiple Endocrine Neoplasia, Type 2b

Multiple Endocrine Neoplasia, Type IIb

Multiple Endocrine Neoplasms Type 2b

Neoplasia, Multiple Endocrine Type 2b

Neoplasms, Multiple Endocrine Type 2b

Neuroma Syndrome, Mucosal

Neuromata, Mucosal, With Endocrine Tumors

Syndrome, Wagenmann-Froboese

Wagenmann Froboese Syndrome

Wagenmann-Froboese Syndrome

Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.