Nesidioblastosis

Synonyms

Hyperinsulinism, Familial, with Pancreatic Nesidioblastosis

Nesidioblastoses

Nesidioblastoses, Pancreatic

Nesidioblastosis of Pancreas

Nesidioblastosis, Pancreatic

Pancreas Nesidioblastoses

Pancreas Nesidioblastosis

Pancreatic Nesidioblastoses

Pancreatic Nesidioblastosis

An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.