NLR Family, Pyrin Domain-Containing 3 Protein


Cold Autoinflammatory Syndrome 1 Protein

NACHT, LRR and PYD Domains Containing Protein 3

NACHT, LRR and PYD Domains-Containing Protein 3

NLR Family, Pyrin Domain Containing 3 Protein

NLRP3 Protein

An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.