Paralyses, Familial Periodic

Synonyms

Familial Periodic Paralyses

Familial Periodic Paralysis

Normokalemic Periodic Paralyses

Normokalemic Periodic Paralysis

Paralyses, Normokalemic Periodic

Paralysis, Familial Periodic

Paralysis, Normokalemic Periodic

Periodic Paralyses, Familial

Periodic Paralyses, Normokalemic

Periodic Paralysis, Familial

Periodic Paralysis, Normokalemic

A heterogenous group of inherited disorders characterized by recurring attacks of rapidly progressive flaccid paralysis or myotonia. These conditions have in common a mutation of the gene encoding the alpha subunit of the sodium channel in skeletal muscle. They are frequently associated with fluctuations in serum potassium levels. Periodic paralysis may also occur as a non-familial process secondary to THYROTOXICOSIS and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1481)