Sotos Syndrome


Cerebral Gigantism

Cerebral Gigantisms

Gigantism, Cerebral

Gigantisms, Cerebral

Sequence, Sotos

Soto Syndrome

Soto's Syndrome

Sotos Sequence

Sotos' Syndrome

Syndrome, Sotos

Syndrome, Sotos'

Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.