Tetrahydrofolate Dehydrogenase


5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase

Acid Reductase, Folic

Dehydrogenase, Dihydrofolate

Dehydrogenase, Tetrahydrofolate

Dihydrofolate Dehydrogenase

Dihydrofolate Reductase

Folic Acid Reductase

Reductase, Dihydrofolate

Reductase, Folic Acid

An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC