Werner Syndrome Helicase
Helicase, Werner Syndrome
Werner Syndrome ATP Dependent Helicase
Werner Syndrome ATP-Dependent Helicase
Werner Syndrome RecQ Like Helicase
Werner Syndrome RecQ-Like Helicase
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.