25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Synonyms
1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
1-alpha-Hydroxylase, 25-Hydroxyvitamin D
1-hydroxylase, 25-Hydroxyvitamin D2
25 Hydroxycholecalciferol 1 Hydroxylase
25 Hydroxyergocalciferol 1 alpha Hydroxylase
25 Hydroxyvitamin D 1 alpha Hydroxylase
25 Hydroxyvitamin D2 1 hydroxylase
25 Hydroxyvitamin D3 1 alpha Hydroxylase
25-Hydroxycholecalciferol 1-Hydroxylase
25-Hydroxycholecalciferol-1-Hydroxylase
25-Hydroxyergocalciferol 1-alpha-Hydroxylase
25-Hydroxyvitamin D 1-alpha-Hydroxylase
25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
25-Hydroxyvitamin D2 1-hydroxylase
CYP27B1
Calcidiol 1 Monooxygenase
Calcidiol 1-Monooxygenase
Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
Cytochrome P 450 CYP27B1
Cytochrome P-450 CYP27B1
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).