ADAMTS13 Protein
Synonyms
A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein
ADAMTS 13 Protein
ADAMTS-13 Protein
ADAMTS13 Protease
vWF Cleaving Protease
vWF-Cleaving Protease
von Willebrand Factor Cleaving Protease
von Willebrand Factor-Cleaving Protease
An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA.