alpha Karyopherins
Synonyms
Importin-alpha
Karyopherin alpha
Karyopherins, alpha
NLS Receptor
NLS-Binding Protein
NLSBP
Nuclear Localization Sequence Receptor
Nuclear Localization Signal-Binding Protein
receptor, NLS
Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
See Also