alpha-Mannosidase
Synonyms
LAMAN
Lysosomal alpha Mannosidase
Lysosomal alpha-Mannosidase
Mannohydrolase, alpha-D-Mannoside
Mannosidase B, alpha
Neutral alpha Mannosidase
Neutral alpha-Mannosidase
alpha D Mannosidase
alpha D Mannoside Mannohydrolase
alpha Mannosidase
alpha Mannosidase B
alpha-D-Mannosidase
alpha-D-Mannoside Mannohydrolase
alpha-Mannosidase, Lysosomal
alpha-Mannosidase, Neutral
An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
See Also